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Publication : Taurine deficiency as a driver of aging.

First Author  Singh P Year  2023
Journal  Science Volume  380
Issue  6649 Pages  eabn9257
PubMed ID  37289866 Mgi Jnum  J:337205
Mgi Id  MGI:7493536 Doi  10.1126/science.abn9257
Citation  Singh P, et al. (2023) Taurine deficiency as a driver of aging. Science 380(6649):eabn9257
abstractText  Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.
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