| Primary Identifier | MGI:6275012 | Allele Type | Transgenic |
| Attribute String | Dominant negative, Inserted expressed sequence | Gene | Tg(Myh6-Kcnj11*)1Wco |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The alpha-myosin heavy chain promoter drives cardiac-specific expression of a dominant negative mouse Kcnj11 mutant, in which the subunit pore region was mutated from glycine-phenylalanine-glycine to three alanines, with a FLAG tag. RT-PCR and Western blotting confirmed expression of the transgene specifically in the heart. Several lines were made but only one was further analyzed. |
