| Primary Identifier | MGI:6272388 | Allele Type | Endonuclease-mediated |
| Attribute String | Not Specified | Gene | Smcr8 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The CRISPR/Cas9 system and sgRNA 5'-GATCAGCGCCCCTGATGTGG-3' was used. Mice contain three separate point mutations on chromosome 11: 60,778,032 (T>C), 60,778,048 (G>A), and 60,778,078 (G>A). The first mutation results in an isoleucine-to-threonine change in amino acid 2 (p.I2T) of the SMCR8 protein while the latter two are silent and result in no coding changes. |
