| Primary Identifier | MGI:6286116 | Allele Type | Chemically induced (ENU) |
| Attribute String | Not Specified | Gene | Casp8 |
| Inheritance Mode | Dominant | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| Project Collection | Beutler Mutagenetix |
| description | https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3723 |
| molecularNote | ENU-induced T to A transversion at base pair 58,833,698 (GRCm38) on chromosome 1, or base pair 38,471 in the GenBank genomic region NC_000067 encoding caspase-8. The mutation corresponds to residue 1,125 in the mRNA sequence NM_009812, within 7 of 9 exons. The mutation results in a histidine to glutamine substitution at position 244 (H244Q) in the caspase-8 protein (isoform 1). |
