| Primary Identifier | MGI:6286071 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | Arid1b |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology using the Cas9D10A and gRNAs 5'-CCAGGCACAGTACCTGCAGC-3' and 5'-GGCGGGAGGTGCGAGGGCTG-3', generated a deletion in exon 3 that causes a frameshift in translation and premature termination. RNA expression in whole brain of heterozygotes is reduced to about 70% of the level in wild-type while protein is reduced to about 50% of that in wild-type mice. |
