Primary Identifier | MGI:6281960 | Allele Type | Targeted |
Attribute String | Not Specified | Gene | Adm |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The targeting construct inserted into the 3' UTR downstream of the translation stop codon contains a loxP site, the bovine growth hormone polyadenylation sequence, 2 tandem copies of the 1.2-kb 5' insulator sequence from chicken beta-globin gene, neomycin resistance cassette, loxP site and 80 bp of AU/U-rich element of the mouse Fos gene. Cre-mediated recombination removed the bovine growth hormone polyadenylation sequence through the neomycin resistance cassette. |