| Primary Identifier | MGI:6277992 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Nrg3 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A loxP-flanked neomycin cassette replaced exon 2 of the gene, which encodes the N-terminal part of the epidermal growth factor-like domain in the encoded protein. Deletion of exon 2 introduces a frameshift mutation in the truncated transcript. Western blot analysis of brain lysates showed that no detectable encoded protein was present in homozygous mice. |
