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Allele : Gt(ROSA)26Sor<tm1(DUX4)Sqh> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Scott Harper
Primary Identifier  MGI:6273758 Allele Type  Targeted
Attribute String  Conditional ready, Epitope tag, Humanized sequence, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  129S6/SvEvTac
Is Recombinase  false Is Wild Type  false
molecularNote  The targeting construct contains from 5' to 3': a loxP-flanked transcriptional STOP cassette (neomycin cassette in reverse orientation) driven by the PGK promoter followed by human DUX4 exon 1 fused to a V5 epitope sequence, exon 2, exon 3, and a BGH polyA. Exon 3 derives from the chrom 4q pLAM region and contains the non-canonical 5'-ATTAAA-3' poly A signal utilized by the last DUX4 copy in facioscapulohumeral muscular dystrophy (FSHD) patients. The vector is inserted in the first intron of Gt(ROSA)26Sor locus.
  • mutations:
  • Insertion
  • synonyms:
  • ROSA26-DUX4,
  • ROSA26-DUX4
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1 Feature

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Genome

1 Expresses

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0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Driven By

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