Primary Identifier | MGI:6278302 | Allele Type | Transgenic |
Attribute String | Humanized sequence, Inducible, Inserted expressed sequence | Gene | Tg(tetO-CHMP2B*)3Fbga |
Strain of Origin | Not Specified | Induced With | doxycycline/tetracycline |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The human CHMP2B cDNA containing a missense mutation in the splice acceptor site of exon 6, a mutation identified in human familial FTD, is under the control of the tetracycline promoter. The mutation results in a truncation at the carboxy terminus such that the microtubule interacting and trafficking motif is lost. |