| Primary Identifier | MGI:6287305 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Sting1 |
| Strain of Origin | C57BL/6N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/cas9 endonuclease-mediated genome editing is used to insert two nucleotide missense mutations in exon 5 of the gene. The mutation results in an amino acid substitution at position 153 altering asparagine to serine (N153S; AAT to TCT). The STING N153S mutation is analogous to the N154S mutation in human TMEM173. N154S is associated with (STING)-associated vasculopathy with onset in infancy (SAVI). |
