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Allele : Gsdmd<em2Broz> gasdermin D; endonuclease-mediated mutation 2, Petr Broz

Primary Identifier  MGI:6285140 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Gsdmd
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR-targeting altered the sequence from AT to CC within exon 2 in order to introduce an alanine for aspartic acid at position 88 (D88A) amino acid substitution. A silent G to C mutation was also introduced to destroy the PAM sequence.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • GSDMD<D88A>,
  • GSDMD<D88A>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

5 Publication categories

Trail: Allele