| First Author | Asai H | Year | 2020 |
| Journal | Mol Brain | Volume | 13 |
| Issue | 1 | Pages | 7 |
| PubMed ID | 31959219 | Mgi Jnum | J:302805 |
| Mgi Id | MGI:6510053 | Doi | 10.1186/s13041-020-0547-z |
| Citation | Asai H, et al. (2020) Pcdhbeta deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination. Mol Brain 13(1):7 |
| abstractText | Clustered protocadherins (Pcdhs), a large group of adhesion molecules, are important for axonal projections and dendritic spread, but little is known about how they influence neuronal activity. The Pcdhbeta cluster is strongly expressed in the hippocampus, and in vivo Ca(2+) imaging in Pcdhbeta-deficient mice revealed altered activity of neuronal ensembles but not of individual cells in this region in freely moving animals. Specifically, Pcdhbeta deficiency increased the number of large-size neuronal ensembles and the proportion of cells shared between ensembles. Furthermore, Pcdhbeta-deficient mice exhibited reduced repetitive neuronal population activity during exploration of a novel context and were less able to discriminate contexts in a contextual fear conditioning paradigm. These results suggest that one function of Pcdhbetas is to modulate neural ensemble activity in the hippocampus to promote context discrimination. |
