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Allele : Rr102<tm1.1Ics> regulatory region 102; targeted mutation 1.1, Mouse Clinical Institute
Primary Identifier  MGI:6336128 Allele Type  Targeted
Attribute String  Conditional ready, Modified regulatory region Gene  Rr102
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  An FRT site flanked neomycin resistance gene cassette and a loxP site flanked chicken transcriptional enhancer element A that contains specific mutations in the Egr2 binding sites that prevent binding of wild-type Egr2 and instead allow binding of a mutant Egr2 (Krox20) protein, and an F3 site flanked mouse element A replaced the wild-type autoregulatory element A. Flp-mediated recombination removed the F3 flanked mouse element A and the neo cassette such that the chicken element A is expressed.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • Krox20<A*>,
  • Egr2<tm1.1Ics>,
  • Krox20<A*>,
  • Egr2<tm1.1Ics>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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Trail: Allele

0 Driven By

3 Publication categories

Trail: Allele




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