| Primary Identifier | MGI:6363499 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Septin12 |
| Transmission | Germline | Strain of Origin | 129 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A G>A nucleotide substitution was introduced into BAC clone bMQ-374d12 to change codon 195 from aspartic acid to asparagine (p.D195N, equivalent to p.D197N in the human ortholog). The BAC was then used in the targeting vector to replace the endogenous sequence through homologous recombination. The equivalent mutation in human is associated with male infertility. |
