| First Author | Tsutsumi S | Year | 2019 |
| Journal | Elife | Volume | 8 |
| PubMed ID | 31596238 | Mgi Jnum | J:301452 |
| Mgi Id | MGI:6383766 | Doi | 10.7554/eLife.47021 |
| Citation | Tsutsumi S, et al. (2019) Modular organization of cerebellar climbing fiber inputs during goal-directed behavior. Elife 8:e47021 |
| abstractText | The cerebellum has a parasagittal modular architecture characterized by precisely organized climbing fiber (CF) projections that are congruent with alternating aldolase C/zebrin II expression. However, the behavioral relevance of CF inputs into individual modules remains poorly understood. Here, we used two-photon calcium imaging in the cerebellar hemisphere Crus II in mice performing an auditory go/no-go task to investigate the functional differences in CF inputs to modules. CF signals in medial modules show anticipatory decreases, early increases, secondary increases, and reward-related increases or decreases, which represent quick motor initiation, go cues, fast motor behavior, and positive reward outcomes. CF signals in lateral modules show early increases and reward-related decreases, which represent no-go and/or go cues and positive reward outcomes. The boundaries of CF functions broadly correspond to those of aldolase C patterning. These results indicate that spatially segregated CF inputs in different modules play distinct roles in the execution of goal-directed behavior. |
