| First Author | Miyazaki H | Year | 2014 |
| Journal | Nat Commun | Volume | 5 |
| Pages | 5525 | PubMed ID | 25413837 |
| Mgi Jnum | J:276267 | Mgi Id | MGI:6296414 |
| Doi | 10.1038/ncomms6525 | Citation | Miyazaki H, et al. (2014) Singular localization of sodium channel beta4 subunit in unmyelinated fibres and its role in the striatum. Nat Commun 5:5525 |
| abstractText | Voltage-gated Na(+) channel beta-subunits are multifunctional molecules that modulate Na(+) channel activity and regulate cell adhesion, migration and neurite outgrowth. beta-subunits including beta4 are known to be highly concentrated in the nodes of Ranvier and axon initial segments in myelinated axons. Here we show diffuse beta4 localization in striatal projection fibres using transgenic mice that express fluorescent protein in those fibres. These axons are unmyelinated, forming large, inhibitory fibre bundles. Furthermore, we report beta4 dimer expression in the mouse brain, with high levels of beta4 dimers in the striatal projection fascicles, suggesting a specific role of beta4 in those fibres. Scn4b-deficient mice show a resurgent Na(+) current reduction, decreased repetitive firing frequency in medium spiny neurons and increased failure rates of inhibitory postsynaptic currents evoked with repetitive stimulation, indicating an in vivo channel regulatory role of beta4 in the striatum. |
