| First Author | Benzow K | Year | 2024 |
| Journal | Alzheimers Dement | Volume | 20 |
| Issue | 4 | Pages | 3080-3087 |
| PubMed ID | 38343132 | Mgi Jnum | J:347607 |
| Mgi Id | MGI:7624532 | Doi | 10.1002/alz.13730 |
| Citation | Benzow K, et al. (2024) Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice. Alzheimers Dement 20(4):3080-3087 |
| abstractText | INTRODUCTION: Genetic studies conducted over the past four decades have provided us with a detailed catalog of genes that play critical roles in the etiology of Alzheimer's disease (AD) and related dementias (ADRDs). Despite this progress, as a field we have had only limited success in incorporating this rich complexity of human AD/ADRD genetics findings into our animal models of these diseases. Our primary goal for the gene replacement (GR)-AD project is to develop mouse lines that model the genetics of AD/ADRD as closely as possible. METHODS: To do this, we are generating mouse lines in which the genes of interest are precisely and completely replaced in the mouse genome by their full human orthologs. RESULTS: Each model set consists of a control line with a wild-type human allele and variant lines that precisely match the human genomic sequence in the control line except for a high-impact pathogenic mutation or risk variant. |
