| Primary Identifier | MGI:6358294 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Tmem43 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Using CRISPR/Cas9 with a donor oligonucleotide, a double substitution was introduced (CC>TA) to change serine codon 358 (TCC) to a leucine codon (TTA) (p.Ser358Leu). This mutation mimics the mutation seen in human arrhythmogenic right ventricular cardiomyopathy (ARVC) patients. |
