| First Author | Allred MG | Year | 2021 |
| Journal | Int J Mol Sci | Volume | 22 |
| Issue | 7 | PubMed ID | 33916486 |
| Mgi Jnum | J:307072 | Mgi Id | MGI:6718164 |
| Doi | 10.3390/ijms22073767 | Citation | Allred MG, et al. (2021) Characterization of Type I Interferon-Associated Chemokines and Cytokines in Lacrimal Glands of Nonobese Diabetic Mice. Int J Mol Sci 22(7) |
| abstractText | Type I interferons (IFNs) are required for spontaneous lacrimal gland inflammation in the nonobese diabetic (NOD) mouse model of Sjogren's disease, but the consequences of type I IFN signaling are not well-defined. Here, we use RNA sequencing to define cytokine and chemokine genes upregulated in lacrimal glands of NOD mice in a type I IFN-dependent manner. Interleukin (IL)-21 was the highest differentially expressed cytokine gene, and Il21 knockout NOD mice were relatively protected from lacrimal gland inflammation. We defined a set of chemokines upregulated early in disease including Cxcl9 and Cxcl10, which share a receptor, CXCR3. CXCR3(+) T cells were enriched in lacrimal glands with a dominant proportion of CXCR3(+) regulatory T cells. Together these data define the early cytokine and chemokine signals associated with type I IFN-signaling in the development of lacrimal gland inflammation in NOD mice providing insight into the role of type I IFN in autoimmunity development. |
