| Primary Identifier | MGI:6363571 | Allele Type | Endonuclease-mediated |
| Attribute String | Hypomorph | Gene | Myo3a |
| Strain of Origin | CBA/CaJ | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Using CRISPR/Cas9 technology and an sgRNA and a donor oligonucleotide, an A>G (c.410A>G) mutation was introduced that changes tyrosine codon 137 into a cysteine codon (p.Y137C). This mutation mimics the human Y129C mutation associated with age-related hearing loss (ARHL). |
