| First Author | Kawai T | Year | 2018 |
| Journal | Channels (Austin) | Volume | 12 |
| Issue | 1 | Pages | 1-8 |
| PubMed ID | 28961043 | Mgi Jnum | J:279635 |
| Mgi Id | MGI:6363805 | Doi | 10.1080/19336950.2017.1385684 |
| Citation | Kawai T, et al. (2018) Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1). Channels (Austin) 12(1):1-8 |
| abstractText | Voltage-gated proton channels (VSOP/Hv1) reportedly promote reactive oxygen species (ROS) production in several immune cell types. However, we recently reported that primary microglia from VSOP/Hv1-deficient mice show higher ROS production than those from WT mice. Microglia may show a distinct activation status between WT and VSOP/Hv1-deficient cells, leading to a distinct level of ROS production between them. This is unlikely, however, because ROS production in VSOP/Hv1-deficient microglia remained higher than in WT microglia when the cells were exposed to LPS. Further, this increase in ROS production in VSOP/Hv1-deficient cells was not observed in macrophages, which suggests microglia have a unique mechanism of VSOP/Hv1-dependent ROS regulation. The mechanism underlying this unconventional ROS regulation by VSOP/Hv1 in microglia is discussed. |
