| First Author | Su Y | Year | 2019 |
| Journal | Cell Death Differ | PubMed ID | 31332295 |
| Mgi Jnum | J:283617 | Mgi Id | MGI:6355775 |
| Doi | 10.1038/s41418-019-0390-x | Citation | Su Y, et al. (2019) Fate decision of satellite cell differentiation and self-renewal by miR-31-IL34 axis. Cell Death Differ |
| abstractText | Quiescent satellite cells (SCs) that are activated to produce numerous myoblasts underpin the complete healing of damaged skeletal muscle. How cell-autonomous regulatory mechanisms modulate the balance among cells committed to differentiation and those committed to self-renewal to maintain the stem cell pool remains poorly explored. Here, we show that miR-31 inactivation compromises muscle regeneration in adult mice by impairing the expansion of myoblasts. miR-31 is pivotal for SC proliferation, and its deletion promotes asymmetric cell fate segregation of proliferating cells, resulting in enhanced myogenic commitment and re-entry into quiescence. Further analysis revealed that miR-31 posttranscriptionally suppresses interleukin 34 (IL34) mRNA, the protein product of which activates JAK-STAT3 signaling required for myogenic progression. IL34 inhibition rescues the regenerative deficiency of miR-31 knockout mice. Our results provide evidence that targeting miR-31 or IL34 activities in SCs could be used to counteract the functional exhaustion of SCs in pathological conditions. |
