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Allele : Col1a1<tm1(tetO-MAPT*P301L)Mdk> collagen, type I, alpha 1; targeted mutation 1, Michael D Koob
Primary Identifier  MGI:6360691 Allele Type  Targeted
Attribute String  Humanized sequence, Inducible, Inserted expressed sequence Gene  Col1a1
Transmission  Germline Strain of Origin  (C57BL/6 x 129S4/SvJae)F1
Induced With  doxycycline/tetracycline Is Recombinase  false
Is Wild Type  false
molecularNote  The targeting construct includes a Tet-responsive element (TRE or tetO) and mouse prion protein promoter sequences (PrP or Prnp) directing expression of the P301L mutant variant of human microtubule-associated protein tau (MAPT) inserted into an intergenic site downstream of Col1A1. The construct, a "Flp-In" promoter cassette (PGK-promoter-ATG-FRT) and a pCAGGS-FlpE plasmid were electroporated into modified V6.5 embryonic stem cells that had previously been targeted with a Col1a1 "Flp-In" integration cassette (Col1a1-FRT-hygro-pA).
  • mutations:
  • Insertion
  • synonyms:
  • T2,
  • rT2,
  • T2,
  • rT2
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1 Feature

Trail: Allele

Genome

1 Expresses

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0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

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1 Driven By

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4 Publication categories

Trail: Allele




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