| Primary Identifier | MGI:6367562 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | Spg11 |
| Inheritance Mode | Not Specified | Strain of Origin | C57BL/6NJ |
| Is Recombinase | false | Is Wild Type | false |
| Project Collection | IMPC |
| molecularNote | This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GATCTAACTGCATAGCAAAG and CTTACCATCCTGTTACAGAA, which resulted in a 499 bp deletion beginning at Chromosome 2 position 122,111,622 bp and ending after 122,112,120 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001285422 (exon 4) and 306 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 218 and early truncation 23 amino acids later. |
