| Primary Identifier | MGI:6361462 | Allele Type | Endonuclease-mediated |
| Attribute String | Inducible, Recombinase | Gene | Nrg1 |
| Strain of Origin | Not Specified | Induced With | tamoxifen |
| Is Recombinase | true | Is Wild Type | false |
| molecularNote | The mouse line was generated by homologous recombination using the CRISPR/Cas9 technology. A complementary DNA encoding Cre recombinase fused with a mutant form of the ESR hormone-binding domain (CreERT2) followed by a polyadenylation sequence, was inserted into the last coding exon of Nrg1 gene, and a 2A peptide sequence was used to link the Nrg1 coding region and CreERT2 cDNA to allow expression of both Nrg1 and CreERT2. |
