| Primary Identifier | MGI:6369097 | Allele Type | Targeted |
| Attribute String | Conditional ready, Humanized sequence, Null/knockout | Gene | Asxl1 |
| Transmission | Germline | Strain of Origin | C57BL/6N |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A single G nucleotide was inserted at position 1925 in exon 13, resulting in a reading frameshift and premature stop codon (p.G643WfsX12). This mutation is equivalent to p.G646WfsX12, the most common mutation in the human ortholog. LoxP sites were inserted into introns 11 and 12. The FRT site flanked neomycin resistance gene cassette that was inserted downstream of the loxP site in intron 12, was removed through subsequent flp-mediated recombination. |
