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Allele : Gt(ROSA)26Sor<tm4.2(CAG-HRP)Ddg> gene trap ROSA 26, Philippe Soriano; targeted mutation 4.2, David D. Ginty
Primary Identifier  MGI:6385514 Allele Type  Targeted
Attribute String  Conditional ready, Reporter Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  129S4/SvJae
Is Recombinase  false Is Wild Type  false
molecularNote  The targeting vector is created by replacing the tdTomato cassette in Gt(ROSA)26Sortm65.1(CAG-tdTomato)Hze with DR-SV-HRP, a dual (Cre and Flp) recombinase (DR)-dependent, synaptic vesicle (SV)-targeted, horse radish peroxidase (HRP) reporter cassette. The following was introduced to intron 1 of the mouse Gt(ROSA)26Sor gene - CAG-FRT-Stop-FRT-loxP-Stop-loxP-SV (synaptophysin protein, a synaptic vesicle targeting peptide)-HRP (horse radish peroxidase)-WPRE (Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element)-bGHpA (bovine growth hormone polyadenylation signal)-attB-PGK-NeoR-PGKpA-attP. Cre-mediated recombination removed the loxP-Stop-loxP component of the construct, leaving the FRT-Stop-FRT feature.
  • mutations:
  • Insertion
  • synonyms:
  • ROSA26<FSF-SV-HRP>,
  • ROSA26<FSF-SV-HRP>
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