| First Author | Oyesola OO | Year | 2023 |
| Journal | Sci Immunol | Volume | 8 |
| Issue | 86 | Pages | eadf8161 |
| PubMed ID | 37566678 | Mgi Jnum | J:358393 |
| Mgi Id | MGI:7780313 | Doi | 10.1126/sciimmunol.adf8161 |
| Citation | Oyesola OO, et al. (2023) Exposure to lung-migrating helminth protects against murine SARS-CoV-2 infection through macrophage-dependent T cell activation. Sci Immunol 8(86):eadf8161 |
| abstractText | Helminth endemic regions report lower COVID-19 morbidity and mortality. Here, we show that lung remodeling from a prior infection with a lung-migrating helminth, Nippostrongylus brasiliensis, enhances viral clearance and survival of human-ACE2 transgenic mice challenged with SARS-CoV-2 (SCV2). This protection is associated with a lymphocytic infiltrate, including increased accumulation of pulmonary SCV2-specific CD8(+) T cells, and anti-CD8 antibody depletion abrogated the N. brasiliensis-mediated reduction in viral loads. Pulmonary macrophages with a type 2 transcriptional and epigenetic signature persist in the lungs of N. brasiliensis-exposed mice after clearance of the parasite and establish a primed environment for increased CD8(+) T cell recruitment and activation. Accordingly, depletion of macrophages ablated the augmented viral clearance and accumulation of CD8(+) T cells driven by prior N. brasiliensis infection. Together, these findings support the concept that lung-migrating helminths can limit disease severity during SCV2 infection through macrophage-dependent enhancement of antiviral CD8(+) T cell responses. |
