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Allele : Asah1<tm1.2Geno> N-acylsphingosine amidohydrolase 1; targeted mutation 1.2, Genoway
Primary Identifier  MGI:6401408 Allele Type  Targeted
Attribute String  Altered localization Gene  Asah1
Transmission  Germline Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 1, encoding the enzymes signal peptide, was flanked by loxP sites. An FRT-flanked neomycin selection cassette was inserted and removed via Flp-mediated recombination. Exon 1 was deleted via cre-mediated recombination in the germline. Removal of the signal peptide disrupts lysosomal targeting of the enzyme. Mice exhibit reduced ceramidase activity in liver, spleen, thymus, and bone marrow.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • Asah1<tmEx1>,
  • Asah1<tmEx1>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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6 Publication categories

Trail: Allele




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