| Primary Identifier | MGI:6400999 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Dpp4 |
| Transmission | Germline | Strain of Origin | C57BL/6NTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exons 10-12 (from codon I264 in exon 10 to codon V340 in exon 12) of the mouse were replaced with the corresponding human exons of 10-12 which comprise the critical Middle East respiratory syndrome coronavirus (MERS-CoV) receptor. A neomycin resistance gene flanked by FRT sites and a puromycin resistance gene flanked by F3 sites were inserted in intron 9 and intron 12, respectively. The selection markers were removed via Flp-mediated recombination. |
