Primary Identifier | MGI:6401814 | Allele Type | Targeted |
Attribute String | Conditional ready, Hypomorph | Gene | Col6a1 |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | An A to G change at position 847 resulting in a glycine to arginine substitution at amino acid 283 was inserted in exon 9 and a FRT and loxP-flanked neomycin selection cassette was inserted in intron 9. Mice show a reduction of mRNA levels and only aberrant spliced products from exon 9 to the neo cassette, suggesting a frame-shift after exon 9. |