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Publication : Systemic immune activation leads to neuroinflammation and sickness behavior in mice.

First Author  Biesmans S Year  2013
Journal  Mediators Inflamm Volume  2013
Pages  271359 PubMed ID  23935246
Mgi Jnum  J:288567 Mgi Id  MGI:6433704
Doi  10.1155/2013/271359 Citation  Biesmans S, et al. (2013) Systemic immune activation leads to neuroinflammation and sickness behavior in mice. Mediators Inflamm 2013:271359
abstractText  Substantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In these experiments, we tested the hypothesis that peripheral immune activation leads to neuroinflammation and depressive-like behavior in mice. We report that systemic administration of LPS induced astrocyte activation in transgenic GFAP-luc mice and increased immunoreactivity against the microglial marker ionized calcium-binding adapter molecule 1 in the dentate gyrus of wild-type mice. Furthermore, LPS treatment caused a strong but transient increase in cytokine levels in the serum and brain. In addition to studying LPS-induced neuroinflammation, we tested whether sickness could be separated from depressive-like behavior by evaluating LPS-treated mice in a panel of behavioral paradigms. Our behavioral data indicate that systemic LPS administration caused sickness and mild depressive-like behavior. However, due to the overlapping time course and mild effects on depression-related behavior per se, it was not possible to separate sickness from depressive-like behavior in the present rodent model.
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