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Allele : Mapt<tm1.1(MAPT)Tcs> microtubule-associated protein tau; targeted mutation 1.1, Takaomi C Saido
Primary Identifier  MGI:6414668 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Mapt
Transmission  Germline Strain of Origin  (C57BL/6NTac x 129S6/SvEvTac)F1
Is Recombinase  false Is Wild Type  false
molecularNote  The human MAPT sequence from exon 1 to exon 14 (NCBI Reference Sequence: NG_007398 with H2 haplotype) and a loxP/FRT flanked neomycin resistance gene replaced the entire genomic sequence (from exon 1 to exon 14) of murine Mapt via homologous recombination. Cre-mediated recombination removed the neomycin gene. Western blot analysis confirmed the expression of all human tau isoforms.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • hTau-KI,
  • hTau-KI
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

7 Carried By

Trail: Allele

0 Driven By

8 Publication categories

Trail: Allele




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