| Primary Identifier | MGI:6446108 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Sh2b1 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/cas9 endonuclease-mediated genome editing was used to create two amino acid deletions at positions P317 and R318 in exon 3 of the gene. The deletions are located in the pleckstrin domain (PH) and are in proximity to two orthologous human mutations. The mutations minimally affect expression levels. |
