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Allele : Il1a<tm1.1Itl> interleukin 1 alpha; targeted mutation 1.1, Ingenious Targeting Laboratory

Primary Identifier  MGI:6450060 Allele Type  Targeted
Attribute String  Null/knockout Gene  Il1a
Transmission  Germline Strain of Origin  C57BL/6NTac
Is Recombinase  false Is Wild Type  false
molecularNote  A point mutation was inserted into exon 5 such that codon 114 is altered from arginine to glutamine. An frt-flanked neomycin selection cassette was removed via Flp-mediated recombination. This mutation renders the encoded protein to be resistant to cleavage by thrombin.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • IL-1alphaTM,
  • R114Q,
  • R114Q,
  • IL-1alphaTM
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

5 Publication categories

Trail: Allele