| First Author | Kollias G | Year | 1987 |
| Journal | Cell | Volume | 51 |
| Issue | 1 | Pages | 21-31 |
| PubMed ID | 2888537 | Mgi Jnum | J:133943 |
| Mgi Id | MGI:3784673 | Doi | 10.1016/0092-8674(87)90006-7 |
| Citation | Kollias G, et al. (1987) Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities. Cell 51(1):21-31 |
| abstractText | Hybrid human--mouse Thy-1.1 genes were injected into pronuclei of Thy-1.2 mice to produce transgenic animals. A hybrid gene composed of the 5' part of the mouse Thy-1.1 gene combined with the 3' human untranslated regions was expressed abnormally in the kidney podocytes, which resulted in severe protein-uria and subsequent death in several founder mice. A hybrid Thy-1 gene composed of the human coding region with the 5' and 3' flanking regions of the mouse gene was expressed abnormally in a different part of the kidney (the tubular epithelia), which resulted in a proliferative kidney disorder. In addition, a neoplasm was found in the brain of one of these mice. These results show that the Thy-1 protein can play an important role in the activation, proliferation, and differentiation of many different cell types. |
