| Primary Identifier | MGI:6452621 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inducible, Recombinase | Gene | Gt(ROSA)26Sor |
| Transmission | Germline | Strain of Origin | C57BL/6J-A<w-J>/J |
| Induced With | tamoxifen | Is Recombinase | true |
| Is Wild Type | false |
| molecularNote | The targeting vector contains from 5' to 3': an adenovirus splice acceptor (SA), the oxygen-dependent degradation (ODD) domain from human HIF1A fused in-frame to the 5' end of Cre recombinase gene fused to the mutated estrogen receptor (cre/ERT2), a polyA tail, and an FRT-flanked neomycin cassette. The HIF1A ODD includes amino acids 371-653 containing prolines P401 and P564. The targeting vector was inserted into intron 1 of the Gt(ROSA)26Sor locus. |
