| Primary Identifier | MGI:6468552 | Allele Type | Targeted |
| Gene | Hspg2 | Transmission | Germline |
| Strain of Origin | C57BL/6N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Exon 91 of the perlecan gene was first replaced by a loxP flanked neo cassette by homologous recombination. The cassette was then removed by breeding with a mouse carrying the Cre recombinase. Since the reading frame is not altered by the deletion, a protein lacking 19 amino acids is produced. The deletion leads to loss of the C-terminal glycosaminoglycan attachment site. |
