|  Help  |  About  |  Contact Us

Allele : Cln3<em1Dprc> CLN3 lysosomal/endosomal transmembrane protein, battenin; endonuclease-mediated mutation 1, David Pearce

Primary Identifier  MGI:6474168 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Cln3
Strain of Origin  C57BL/6 Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 technology introduced a C to T nonsense mutation at position 1054 (c.1054C>T) in exon 16 causing glutamine 352 to be replaced with a premature stop codon (Q352X). Homozygous mice show reduced transcript levels in various tissues.
  • mutations:
  • Single point mutation
  • synonyms:
  • Cln3<Q352X>,
  • Cln3<Q352X>
Quick Links:
 
Quick Links:
 

1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

3 Publication categories

Trail: Allele