| First Author | Tao K | Year | 2016 |
| Journal | Neuroscience | Volume | 318 |
| Pages | 34-44 | PubMed ID | 26794590 |
| Mgi Jnum | J:300434 | Mgi Id | MGI:6502841 |
| Doi | 10.1016/j.neuroscience.2016.01.011 | Citation | Tao K, et al. (2016) Experimental febrile seizures induce age-dependent structural plasticity and improve memory in mice. Neuroscience 318:34-44 |
| abstractText | Population-based studies have demonstrated that children with a history of febrile seizure (FS) perform better than age-matched controls at hippocampus-dependent memory tasks. Here, we report that FSs induce two distinct structural reorganizations in the hippocampus and bidirectionally modify future learning abilities in an age-dependent manner. Compared with age-matched controls, adult mice that had experienced experimental FSs induced by hyperthermia (HT) on postnatal day 14 (P14-HT) performed better in a cognitive task that requires dentate granule cells (DGCs). The enhanced memory performance correlated with an FS-induced persistent increase in the density of large mossy fiber terminals (LMTs) of the DGCs. The memory enhancement was not observed in mice that had experienced HT-induced seizures at P11 which exhibited abnormally located DGCs in addition to the increased LMT density. The ectopic DGCs of the P11-HT mice were abolished by the diuretic bumetanide, and this pharmacological treatment unveiled the masked memory enhancement. Thus, this work provides a novel basis for age-dependent structural plasticity in which FSs influence future brain function. |
