| Primary Identifier | MGI:6506458 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Gt(ROSA)26Sor |
| Transmission | Germline | Strain of Origin | C57BL/6 |
| Is Recombinase | false | Is Wild Type | false |
| description | PRX (C57BL/6) ES cells were used to generate mice, however the specific PRX cell line is not specified in J:280156. |
| molecularNote | A targeting vector, containing human PCSK9 cDNA under the control of a 2.34 kb mouse albumin promoter/enhancer and a floxed cassette containing cre recombinase cDNA under the control of a 698 bp testis-specific angiotensin converting enzyme promotor and neomycin phosphotransferase selection marker driven by the pol II promoter, was inserted into the endogenous locus. Flp-mediated recombination removed the floxed cre and neo cassette. |
