Primary Identifier | MGI:6681833 | Allele Type | Endonuclease-mediated |
Attribute String | Humanized sequence | Gene | Myo9a |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | CRISPR/Cas9 technology generated a C to T mutation in exon 14 which substitutes CGA encoding arginine to TGA, a stop codon that predicts termination of translation at amino acid 701 (p.R701*). This mutation has been identified in a family with focal segmental glomerulosclerosis. |