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Allele : Axl<em1Ebt> AXL receptor tyrosine kinase; endonuclease-mediated mutation 1, Edward B Thorp

Primary Identifier  MGI:6690906 Allele Type  Endonuclease-mediated
Attribute String  Modified isoform(s) Gene  Axl
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 genome editing technology was used to generate a deletion of CCCCCACCTCGCGCCTTC between exons 10 and 11. This deleted a 6–amino acid region of the encoded protein within a 14–amino acid stalk region proximal to the transmembrane domain. The resulting protein is cleavage-resistant.
  • mutations:
  • Intragenic deletion
  • synonyms:
  • Axl<em1Irb>,
  • Axl<em1Irb>,
  • Axl<CR>,
  • Axl<CR>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

3 Publication categories

Trail: Allele