| First Author | Lin M | Year | 2021 |
| Journal | Biochem Biophys Res Commun | Volume | 550 |
| Pages | 127-133 | PubMed ID | 33689881 |
| Mgi Jnum | J:305295 | Mgi Id | MGI:6705950 |
| Doi | 10.1016/j.bbrc.2021.02.143 | Citation | Lin M, et al. (2021) MRNIP is essential for meiotic progression and spermatogenesis in mice. Biochem Biophys Res Commun 550:127-133 |
| abstractText | Meiotic homologous recombination (HR) initiates with the programmed generation of DNA double-strand breaks (DSBs), which result in the exchange of genetic information and genome diversity. This process requires the tight cooperation of the MRE11-RAD50-NBS1 (MRN) complex to promote DSB formation and DNA end resection. However, the mechanism regulating MRN complex remains to be explored. In the present study, we report that MRN-interacting protein, MRNIP, is a novel factor for HR and is crucial for the expression of the MRN complex and loading of recombinases DMC1/RAD51. Knockout of Mrnip in mice led to aberrant synapsis, impaired HR, and male subfertility. In conclusion, MRNIP is a novel HR factor that probably promotes meiotic progression through the MRN complex. |
