| First Author | Fu X | Year | 2019 |
| Journal | Biochem Biophys Res Commun | Volume | 512 |
| Issue | 4 | Pages | 763-769 |
| PubMed ID | 30926163 | Mgi Jnum | J:291224 |
| Mgi Id | MGI:6443364 | Doi | 10.1016/j.bbrc.2019.03.138 |
| Citation | Fu X, et al. (2019) EID1 plays a crucial role in proliferation of neural stem cell. Biochem Biophys Res Commun 512(4):763-769 |
| abstractText | EP300-interacting inhibitor of differentiation 1 (Eid1) regulates differentiation, transcription and acetyltransferase activity. But the main function of Eid1 in the brain is still unclear. To better understand this issue, we generated Eid1-knockout (Eid1-KO) mice. We found poorer learning and memory ability, and smaller volume of neonatal telencephalon in Eid1-KO group than wild-type (WT). Bioinformatics implied that Eid1 may directly regulate cell proliferation. We then isolated neural stem cells (NSCs) and discovered a slower proliferation rate in Eid1-KO NSCs. Moreover, based on bioinformatics results, we investigated the expression of phosphatidylinositol 3-kinase (PI3K)/AKT/GSK3beta pathway by Western blotting assay, which showed attenuated in Eid1-KO group. Our data proved the first comprehensive report of Eid1 regulating NSCs proliferation via PI3K/AKT/GSK3beta pathway, and provide a foundation for the role of EID1 in the brain. |
