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Allele : Gt(ROSA)26Sor<tm1(BEST1-cre/ERT2)Vold> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Douglas Vollrath
Primary Identifier  MGI:6711969 Allele Type  Targeted
Attribute String  Inducible, Recombinase Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Induced With  tamoxifen Is Recombinase  true
Is Wild Type  false
molecularNote  The allele was created to have the human BEST1 promoter/enhancer regions directing the expression of a CreER(T2) fusion gene. The targeting vector contained, from 5' to 3', the human BEST1 promoter (nucleotides -585 to +38), followed by a CreER(T2) fusion gene, and an SV40 a polyA cassette. The plasmid was pronuclear injected into C57BL/6J(attPx3) zygotes along with phiC31 integrase mRNA. The resulting founder mice were bred with C57BL/6J for germline transmission.
  • mutations:
  • Insertion
  • synonyms:
  • Rosa26<BEST1-CreERT2>,
  • Rosa26<BEST1-CreERT2>
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0 Mutation Involves

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