| First Author | Yuan Y | Year | 2019 |
| Journal | FASEB J | Volume | 33 |
| Issue | 10 | Pages | 11148-11162 |
| PubMed ID | 31291551 | Mgi Jnum | J:290673 |
| Mgi Id | MGI:6443296 | Doi | 10.1096/fj.201900588RR |
| Citation | Yuan Y, et al. (2019) PTENalpha regulates endocytosis and modulates olfactory function. FASEB J 33(10):11148-11162 |
| abstractText | Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) alpha is the first identified isoform of the well-known tumor suppressor PTEN. PTENalpha has an evolutionarily conserved 173-aa N terminus compared with canonical PTEN. Recently, PTENalpha has been shown to play roles in multiple biologic processes including learning and memory, cardiac homeostasis, and antiviral immunity. Here, we report that PTENalpha maintains mitral cells in olfactory bulb (OB), regulates endocytosis in OB neurons, and controls olfactory behaviors in mice. We show that PTENalpha directly dephosphorylates the endocytic protein amphiphysin and promotes its binding to adaptor-related protein complex 2 subunit beta1 (Ap2b1). In addition, we identified mutations in the N terminus of PTENalpha in patients with Parkinson disease and Lewy-body dementia, which are neurodegenerative disorders with early olfactory loss. Overexpression of PTENalpha mutant H169N in mice OB reduces odor sensitivity. Our data demonstrate a role of PTENalpha in olfactory function and provide insight into the mechanism of olfactory dysfunction in neurologic disorders.-Yuan, Y., Zhao, X., Wang, P., Mei, F., Zhou, J., Jin, Y., McNutt, M. A., Yin, Y. PTENalpha regulates endocytosis and modulates olfactory function. |
