| First Author | Demaria M | Year | 2014 |
| Journal | Dev Cell | Volume | 31 |
| Issue | 6 | Pages | 722-33 |
| PubMed ID | 25499914 | Mgi Jnum | J:296170 |
| Mgi Id | MGI:6467835 | Doi | 10.1016/j.devcel.2014.11.012 |
| Citation | Demaria M, et al. (2014) An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev Cell 31(6):722-33 |
| abstractText | Cellular senescence suppresses cancer by halting the growth of premalignant cells, yet the accumulation of senescent cells is thought to drive age-related pathology through a senescence-associated secretory phenotype (SASP), the function of which is unclear. To understand the physiological role(s) of the complex senescent phenotype, we generated a mouse model in which senescent cells can be visualized and eliminated in living animals. We show that senescent fibroblasts and endothelial cells appear very early in response to a cutaneous wound, where they accelerate wound closure by inducing myofibroblast differentiation through the secretion of platelet-derived growth factor AA (PDGF-AA). In two mouse models, topical treatment of senescence-free wounds with recombinant PDGF-AA rescued the delayed wound closure and lack of myofibroblast differentiation. These findings define a beneficial role for the SASP in tissue repair and help to explain why the SASP evolved. |
