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Allele : Gt(ROSA)26Sor<tm1(CAG-ECFP*/Venus*)Tpzn> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Tullio Pozzan
Primary Identifier  MGI:6728074 Allele Type  Targeted
Attribute String  Conditional ready, Reporter Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  (129S6/SvEvTac x C57BL/6NCrl)F1
Is Recombinase  false Is Wild Type  false
molecularNote  The targeting vector is designed with (from 5' to 3') a ubiquitously expressed CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (from pCAGGS), a loxP-flanked stop cassette (containing a betageo sequence), and the mt-Cam cDNA. mt-Cam encodes a FRET-based Cameleon calcium sensor (4mtD3cpv) variant containing a codon-optimized elongated mitochondria tag, a donor chromophore enhanced cyan fluorescent protein (ECFP), calcium sensor sequences [calmodulin and a calmodulin-binding domain from myosin light-chain kinase (M13)], and the acceptor chromophore circularly permuted Venus (cpV). This targeting vector is inserted into the Gt(ROSA)26Sor locus in opposite orientation to the Gt(ROSA)26Sor promoter.
  • mutations:
  • Insertion
  • synonyms:
  • mt-Cam,
  • mt-Cam
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Trail: Allele

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0 Mutation Involves

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Mouse alleles --> Mammalian phenotypes (MP terms)

 

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