| Primary Identifier | MGI:6762163 | Allele Type | Targeted |
| Attribute String | Conditional ready | Gene | Dock8 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The targeting vector consists of mouse Dock8 gene encoding exon 3 flanked by two loxP sites, the PGK-neo cassette (Neo) flanked by two flippase recognition target (FRT) sites. After homologous recombination in ES cells and generation of chimeric male founders with correctly targetted ES cells, the PGK-neo cassette was excised by crossing with the CAG-FLPe transgenic mice. Cre-mediated excision of exon 3 results in the appearance of a premature stop codon in exon 4. |
